Polyglutamic Acid
Polyglutamic Acid — a large water-loving polymer, produced by fermentation, that forms a thin film on the skin's surface and holds many times its weight in moisture. It works as a humectant, drawing water toward the outer layers of skin to leave it looking plump and smooth.
Key points
- It is a high-molecular-weight humectant often described as holding significantly more water than hyaluronic acid, though results vary by formulation.
- Because the molecule is large, it tends to sit on the skin surface and form a hydrating, breathable film rather than penetrating deeply.
- It pairs well with hyaluronic acid, as the two can hydrate at different levels of the skin.
- It is generally well tolerated across skin types and is a common choice in serums, essences, and lightweight moisturizers.
Frequently asked
Is polyglutamic acid better than hyaluronic acid?
Neither is strictly better; polyglutamic acid tends to form a surface film that limits water loss, while hyaluronic acid can hydrate at multiple depths, and many formulas combine both.
When should I apply a polyglutamic acid product?
It is typically applied to damp skin after cleansing and before richer creams, so the humectant can draw in and seal moisture.
Related topics
This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.

