Ingredients

Polyglutamic Acid

Polyglutamic Acid — a large water-loving polymer, produced by fermentation, that forms a thin film on the skin's surface and holds many times its weight in moisture. It works as a humectant, drawing water toward the outer layers of skin to leave it looking plump and smooth.

Key points

  • It is a high-molecular-weight humectant often described as holding significantly more water than hyaluronic acid, though results vary by formulation.
  • Because the molecule is large, it tends to sit on the skin surface and form a hydrating, breathable film rather than penetrating deeply.
  • It pairs well with hyaluronic acid, as the two can hydrate at different levels of the skin.
  • It is generally well tolerated across skin types and is a common choice in serums, essences, and lightweight moisturizers.

Frequently asked

Is polyglutamic acid better than hyaluronic acid?

Neither is strictly better; polyglutamic acid tends to form a surface film that limits water loss, while hyaluronic acid can hydrate at multiple depths, and many formulas combine both.

When should I apply a polyglutamic acid product?

It is typically applied to damp skin after cleansing and before richer creams, so the humectant can draw in and seal moisture.

Related topics

This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.

Encyclopedia

Further reading

This entry was written and checked against the sources below. They are published by clinical and scientific bodies, they are listed most readable first, and each one opens in a new tab. They are background for the whole entry rather than footnotes to individual sentences.

  1. In vitro evaluation of new functional properties of poly-gamma-glutamic acid PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  2. Poly (gamma) glutamic acid: a unique microbial biopolymer with diverse commercial applicability PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  3. Natural and edible biopolymer poly-gamma-glutamic acid: synthesis, production, and applications PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov
  4. New biological functions and applications of high-molecular-mass poly-gamma-glutamic acid PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov

SYNC does not publish medical advice. Nothing here replaces a consultation with a doctor or a pharmacist about your own skin.