Azelaic Acid

Azelaic Acid — a naturally occurring dicarboxylic acid, found in grains like barley and wheat, that helps calm redness, even skin tone, and clear breakout-prone skin. It works through several actions, including reducing the appearance of pigmentation and having anti-inflammatory and antibacterial effects. It is often chosen for conditions involving both blemishes and uneven tone.

Key points

  • Azelaic acid is a dicarboxylic acid produced naturally by grains and is not an AHA or BHA.
  • It can help reduce the look of post-blemish marks and uneven pigmentation by interfering with excess melanin production.
  • Its anti-inflammatory and antibacterial properties make it useful for breakout-prone and redness-prone skin.
  • Over-the-counter products commonly contain around 10 percent, while higher concentrations are available by prescription.
  • It is generally well tolerated, though mild tingling or dryness can occur when starting.

Frequently asked

What skin concerns is azelaic acid used for?

It is often used for uneven tone, post-blemish marks, breakouts, and visible redness, thanks to its combined brightening, anti-inflammatory, and antibacterial actions. This makes it versatile for several concerns at once.

Can azelaic acid be used with other actives?

It generally layers well with ingredients like niacinamide and is often considered gentle enough to pair with a range of actives. As always, introduce new products gradually and monitor for irritation.

Related topics

This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.

Encyclopedia

Further reading

This entry was written and checked against the sources below. They are published by clinical and scientific bodies, they are listed most readable first, and each one opens in a new tab. They are background for the whole entry rather than footnotes to individual sentences.

  1. Azelaic acid: Uses, Application and More DermNet NZ Clinical guidance dermnetnz.org
  2. Azelaic acid in the treatment of papulopustular rosacea: a systematic review of randomized controlled trials - Database of Abstracts of Reviews of Effects… StatPearls (NCBI Bookshelf) Reference text ncbi.nlm.nih.gov
  3. Azelaic Acid: Mechanisms of Action and Clinical Applications PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  4. The multiple uses of azelaic acid in dermatology: mechanism of action, preparations, and potential therapeutic applications PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  5. A systematic review to evaluate the efficacy of azelaic acid in the management of acne, rosacea, melasma and skin aging PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov
  6. Efficacy and safety of topical azelaic acid (20 percent cream): an overview of results from European clinical trials and experimental reports PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov

SYNC does not publish medical advice. Nothing here replaces a consultation with a doctor or a pharmacist about your own skin.