Urea

Urea — a component of the skin's own natural moisturizing factor that works as both a humectant and, at higher concentrations, a mild exfoliant. It helps skin hold water at low levels and can soften and smooth rough, thickened, or dry skin at higher levels.

Key points

  • At lower concentrations it acts mainly as a humectant, drawing and binding water to hydrate skin.
  • At higher concentrations it becomes keratolytic, helping to loosen and shed rough or built-up skin cells.
  • It occurs naturally in skin as part of the natural moisturizing factor that keeps the barrier hydrated.
  • It is often used for dry, flaky, or rough areas such as elbows, knees, feet, and body skin.

Frequently asked

Why does urea appear in both moisturizers and exfoliating products?

Its effect depends on concentration; lower levels hydrate as a humectant, while higher levels help soften and remove rough, thickened skin.

Is urea suitable for sensitive skin?

Lower-concentration urea is generally well tolerated, but higher exfoliating strengths may cause tingling on very sensitive or compromised skin, so patch testing is wise.

Related topics

This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.

Encyclopedia

Further reading

This entry was written and checked against the sources below. They are published by clinical and scientific bodies, they are listed most readable first, and each one opens in a new tab. They are background for the whole entry rather than footnotes to individual sentences.

  1. Urea DermNet NZ Clinical guidance dermnetnz.org
  2. Effect of topical treatment with urea in ichthyosis, atopic dermatitis, psoriasis, and other skin conditions-a systematic review PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov
  3. Topical urea in skincare: A review PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov
  4. Moisturizers StatPearls (NCBI Bookshelf) Reference text ncbi.nlm.nih.gov
  5. Atopic Dermatitis and the Stratum Corneum: Part 1: The Role of Filaggrin in the Stratum Corneum Barrier and Atopic Skin PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  6. Natural moisturizing factor as a biomarker for filaggrin PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov

SYNC does not publish medical advice. Nothing here replaces a consultation with a doctor or a pharmacist about your own skin.