Natural Moisturizing Factor (NMF)
Natural Moisturizing Factor (NMF) — a collection of water-attracting compounds within the outer skin cells, including amino acids, urea, lactate, and PCA, that draw and hold moisture in the surface layers. This built-in humectant system helps keep the stratum corneum hydrated and pliable.
Key points
- NMF is composed largely of free amino acids and their derivatives, plus urea, lactate, and salts.
- It is produced in part from the breakdown of a protein called filaggrin during skin cell maturation.
- NMF acts as the skin's own humectant, binding water within the outer layer.
- Low NMF levels are linked to dryness, flaking, and a rough skin surface.
Frequently asked
Where does NMF come from?
Much of it is generated as skin cells mature and the protein filaggrin breaks down into water-binding amino acids and related compounds.
Can skincare support NMF?
Ingredients like amino acids, urea, glycerin, and lactate are used to help supplement the skin's natural moisturizing factor and support hydration.
Related topics
This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.
