Hyaluronic Acid

Hyaluronic Acid — a naturally occurring molecule in skin that can bind and hold large amounts of water, helping keep tissue hydrated and plump. In skincare it is a widely used humectant that draws moisture into the upper skin layers to improve the look of hydration and smoothness.

Key points

  • Hyaluronic acid is a glycosaminoglycan naturally found in the skin and connective tissues.
  • It is a humectant capable of binding many times its weight in water.
  • Different molecular weights sit at different depths, with larger molecules staying near the surface and smaller ones penetrating further.
  • In low-humidity conditions it can draw water from deeper skin, so it is often paired with an occlusive or moisturizer to seal in hydration.

Frequently asked

Does hyaluronic acid work for all skin types?

Hyaluronic acid is a lightweight humectant generally suitable for most skin types, including oily skin, though pairing it with a moisturizer helps lock in hydration.

Should hyaluronic acid be applied to damp or dry skin?

Applying it to slightly damp skin and following with a moisturizer helps it attract and retain water, especially in dry environments.

Related topics

This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.

Encyclopedia

Further reading

This entry was written and checked against the sources below. They are published by clinical and scientific bodies, they are listed most readable first, and each one opens in a new tab. They are background for the whole entry rather than footnotes to individual sentences.

  1. Hyaluronic Acid in Topical Applications: The Various Forms and Biological Effects of a Hero Molecule in the Cosmetics Industry PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  2. Recent Advances of Hyaluronan for Skin Delivery: From Structure to Fabrication Strategies and Applications PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  3. Efficacy Evaluation of a Topical Hyaluronic Acid Serum in Facial Photoaging PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  4. The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an… PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  5. Benefits of topical hyaluronic acid for skin quality and signs ... PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov
  6. Hyaluronic Acid in Topical Applications: The Various Forms and Biological Effects of a Hero Molecule in the Cosmetics Industry PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov

SYNC does not publish medical advice. Nothing here replaces a consultation with a doctor or a pharmacist about your own skin.