How Niacinamide Works
How Niacinamide Works — a form of vitamin B3 that the skin converts into coenzymes central to cellular energy and repair, helping support the barrier and regulate several skin functions. It has been shown to increase production of ceramides and other barrier lipids, temper excess sebum, and reduce the transfer of pigment to surface skin cells. It is generally well tolerated across skin types and pairs easily with most other ingredients.
Key points
- Niacinamide is a precursor to NAD-related coenzymes that fuel skin cell metabolism and repair.
- It boosts synthesis of ceramides and free fatty acids, strengthening the skin barrier and reducing water loss.
- It can limit the transfer of melanosomes to keratinocytes, helping soften the look of uneven pigmentation.
- It has anti-inflammatory and sebum-modulating effects that make it useful for redness and blemish-prone skin.
Frequently asked
What concentration of niacinamide is effective?
Many studies use concentrations around 2 to 5 percent, and higher amounts do not reliably add benefit and may increase the chance of irritation in sensitive skin.
Can niacinamide be used with vitamin C?
Yes; despite older myths, modern formulations of niacinamide and vitamin C can generally be used together without cancelling each other out.
Related topics
This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.
