Enzyme-Inhibitor Peptides
Enzyme-Inhibitor Peptides — short chains of amino acids formulated to slow the activity of specific skin enzymes, most often those involved in collagen and elastin breakdown or in pigment production. By dampening enzymes like collagenase, elastase, or tyrosinase, they aim to support firmer-looking skin and a more even tone. They are typically used at low concentrations in leave-on serums and moisturizers.
Key points
- Unlike signaling peptides that prompt cells to build matrix proteins, enzyme-inhibitor peptides work by blocking or reducing the enzymes that degrade those proteins.
- Common targets include collagenase and elastase, which break down structural proteins, and tyrosinase, a key enzyme in melanin synthesis.
- They are generally gentle and water-soluble, making them suitable for most skin types when used as directed.
- Peptides are often paired with humectants, antioxidants, and other actives, though very low pH formulas can reduce their stability.
- Visible benefits tend to be gradual and require consistent daily use over several weeks.
Frequently asked
How are enzyme-inhibitor peptides different from retinoids?
Retinoids are vitamin A derivatives that broadly influence skin cell turnover and gene activity, while enzyme-inhibitor peptides act more narrowly by reducing specific enzymes such as those that break down collagen or produce pigment. Peptides are usually milder and less likely to cause irritation.
Can I use peptides alongside acids and vitamin C?
In most routines they can be combined, though highly acidic formulas may affect peptide stability, so many people apply them at different times of day. Introduce new actives gradually and follow product instructions.
Related topics
This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.
