Ergothioneine

Ergothioneine — a naturally occurring amino acid with strong antioxidant properties, found in mushrooms and certain other organisms, and used in skincare to help defend against oxidative stress. It is valued for its stability and its ability to help neutralize free radicals that contribute to visible aging.

Key points

  • It is a potent antioxidant that helps protect skin from free radicals generated by UV exposure and environmental pollutants.
  • The human body does not produce it, so it is obtained through diet or applied topically in formulations.
  • It is notably stable compared with some other antioxidants, which can support consistent performance in a formula.
  • It is often used alongside other antioxidants such as vitamin C or vitamin E to broaden environmental defense.

Frequently asked

Is ergothioneine good for sensitive skin?

It is generally considered gentle and well tolerated, though anyone with reactive skin should patch test new products first.

How is ergothioneine different from vitamin C?

Both are antioxidants, but ergothioneine is a stable amino acid that complements vitamin C rather than replacing it, and the two are often used together.

Related topics

This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.

Encyclopedia

Further reading

This entry was written and checked against the sources below. They are published by clinical and scientific bodies, they are listed most readable first, and each one opens in a new tab. They are background for the whole entry rather than footnotes to individual sentences.

  1. Ergothioneine as a Natural Antioxidant Against Oxidative Stress PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  2. Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  3. The biology of ergothioneine, an antioxidant nutraceutical PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  4. Ergothioneine as a promising natural antioxidant: bioactivities, therapeutic potential, and industrial applications PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov
  5. An overview about oxidation in clinical practice of skin aging PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  6. Oxidative stress and antioxidant strategies in dermatology PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov

SYNC does not publish medical advice. Nothing here replaces a consultation with a doctor or a pharmacist about your own skin.