Ergothioneine
Ergothioneine — a naturally occurring amino acid with strong antioxidant properties, found in mushrooms and certain other organisms, and used in skincare to help defend against oxidative stress. It is valued for its stability and its ability to help neutralize free radicals that contribute to visible aging.
Key points
- It is a potent antioxidant that helps protect skin from free radicals generated by UV exposure and environmental pollutants.
- The human body does not produce it, so it is obtained through diet or applied topically in formulations.
- It is notably stable compared with some other antioxidants, which can support consistent performance in a formula.
- It is often used alongside other antioxidants such as vitamin C or vitamin E to broaden environmental defense.
Frequently asked
Is ergothioneine good for sensitive skin?
It is generally considered gentle and well tolerated, though anyone with reactive skin should patch test new products first.
How is ergothioneine different from vitamin C?
Both are antioxidants, but ergothioneine is a stable amino acid that complements vitamin C rather than replacing it, and the two are often used together.
Related topics
This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.

