Ceramides
Ceramides — a class of lipid molecules that make up a large share of the outer skin layer and help hold skin cells together in a protective barrier. In skincare they are used to reinforce this barrier, limit moisture loss, and support the feel of soft, resilient skin.
Key points
- Ceramides are naturally occurring skin lipids that form part of the mortar holding together cells in the outermost layer.
- They work alongside cholesterol and fatty acids to maintain a healthy, water-retaining barrier.
- Ceramide levels can decline with age and in dry or barrier-compromised skin.
- Topical ceramides are used to help reduce transepidermal water loss and support the appearance of hydrated skin.
Frequently asked
Do ceramides work better with other ingredients?
Ceramides are often paired with cholesterol and fatty acids, a combination that reflects the skin's natural barrier composition.
Are ceramides suitable for sensitive skin?
Ceramides are generally well tolerated and barrier-supportive, but as with any product, patch testing is a good precaution for sensitive skin.
Related topics
This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.

