Ingredients

Coenzyme Q10 (Ubiquinone)

Coenzyme Q10 (Ubiquinone) — a fat-soluble antioxidant naturally present in the body's cells, where it plays a role in energy production and helps protect cells from oxidative stress. In its oxidized form, ubiquinone, it is used topically to support antioxidant defense and a smoother, more revitalized-looking complexion, though its natural levels in skin decline with age.

Key points

  • Coenzyme Q10 is an antioxidant found in the mitochondria of cells, where it contributes to cellular energy metabolism.
  • Its levels in the skin naturally decrease with age and cumulative UV exposure.
  • Applied topically, it helps neutralize free radicals and support the skin's defense against environmental stress.
  • Ubiquinone is the oxidized form commonly listed on ingredient labels, while ubiquinol is its reduced counterpart.

Frequently asked

What is the difference between ubiquinone and CoQ10?

They refer to the same molecule; ubiquinone is the oxidized form of coenzyme Q10 and is the version most often used in skincare formulas.

Does topical CoQ10 help with signs of aging?

As an antioxidant it helps protect against free radical damage that contributes to visible aging, and some research suggests it may support smoother-looking skin over time.

Related topics

This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.

Encyclopedia

Further reading

This entry was written and checked against the sources below. They are published by clinical and scientific bodies, they are listed most readable first, and each one opens in a new tab. They are background for the whole entry rather than footnotes to individual sentences.

  1. Coenzyme Q10 NCCIH (NIH) Clinical guidance nccih.nih.gov
  2. The Role of Coenzyme Q10 in Skin Aging and Opportunities for Topical Intervention: A Review PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  3. Coenzyme Q(10) enhances dermal elastin expression, inhibits IL-1α production and melanin synthesis in vitro PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov
  4. Coenzyme Q10, a cutaneous antioxidant and energizer PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov

SYNC does not publish medical advice. Nothing here replaces a consultation with a doctor or a pharmacist about your own skin.