Glossary

TEWL (Transepidermal Water Loss)

TEWL (Transepidermal Water Loss) — the process by which water evaporates from inside the body outward through the skin and into the environment. A certain baseline amount is normal, but an elevated rate can signal a compromised skin barrier that struggles to hold onto moisture.

Key points

  • TEWL measures how much water passes through the epidermis and evaporates from the skin's surface.
  • A low, stable TEWL rate generally reflects a healthy, intact barrier, while a high rate can indicate barrier damage.
  • Factors such as harsh cleansing, low humidity, over-exfoliation, and certain skin conditions can increase TEWL.
  • Occlusive and humectant ingredients are commonly used to help reduce excessive water loss and support hydration.

Frequently asked

Is transepidermal water loss always bad?

No, a small amount of TEWL is a normal part of healthy skin function. It becomes a concern only when the rate is elevated, which can point to a weakened barrier.

How can I lower high TEWL?

Supporting the barrier with gentle cleansing and moisturizers containing humectants, emollients, and occlusives can help reduce excessive water loss. Avoiding over-exfoliation and harsh products also helps.

Related topics

This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.

Encyclopedia

Further reading

This entry was written and checked against the sources below. They are published by clinical and scientific bodies, they are listed most readable first, and each one opens in a new tab. They are background for the whole entry rather than footnotes to individual sentences.

  1. Barrier function in atopic dermatitis DermNet NZ Clinical guidance dermnetnz.org
  2. Skin barrier function DermNet NZ Clinical guidance dermnetnz.org
  3. Transepidermal water loss and skin conductance as barrier integrity tests PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  4. Assessment of skin barrier function using transepidermal water loss: effect of age PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov
  5. Measurement of transepidermal water loss, stratum corneum hydration and skin surface pH in occupational settings: A review PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov

SYNC does not publish medical advice. Nothing here replaces a consultation with a doctor or a pharmacist about your own skin.