Squalene

Squalene — a natural lipid produced by the skin's sebaceous glands and a component of the skin's protective surface oils. Because it oxidizes easily in its natural form, skincare products typically use its more stable derivative, squalane.

Key points

  • Squalene is naturally present in human sebum and helps make up the skin's surface lipid layer.
  • It is an unsaturated compound, which makes it prone to oxidation and less stable in products.
  • Natural squalene production tends to decline with age.
  • To improve stability, brands usually convert squalene into squalane for topical formulations.

Frequently asked

Why do most products use squalane instead of squalene?

Squalene oxidizes quickly, so it is hydrogenated into squalane, a more stable form that resists spoiling and performs better in products.

Where does squalene come from?

Squalene occurs naturally in human skin oil and is also found in plant sources such as olives and in some marine sources.

Related topics

This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.

Encyclopedia

Further reading

This entry was written and checked against the sources below. They are published by clinical and scientific bodies, they are listed most readable first, and each one opens in a new tab. They are background for the whole entry rather than footnotes to individual sentences.

  1. Safety Assessment of Squalane and Squalene as Used in Cosmetics Cosmetic Ingredient Review Regulatory and safety cir-safety.org
  2. Squalene and Squalane CosmeticsInfo Regulatory and safety cosmeticsinfo.org
  3. Biological and Pharmacological Activities of Squalene and Related Compounds PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  4. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov
  5. Biological importance and applications of squalene and squalane PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov

SYNC does not publish medical advice. Nothing here replaces a consultation with a doctor or a pharmacist about your own skin.