Ingredients

Salicylate Derivatives (LHA)

Salicylate Derivatives (LHA) — lipophilic derivatives of salicylic acid, most notably capryloyl salicylic acid (LHA), that exfoliate the skin's surface and inside pores. Their oil-loving nature and larger molecule allow a targeted, layer-by-layer exfoliation often described as gentler and more even than standard salicylic acid.

Key points

  • LHA (capryloyl salicylic acid) is a fatty-chain derivative of salicylic acid with a pH close to that of skin.
  • Its lipophilic structure lets it penetrate sebum-rich pores, making it useful for oily and blemish-prone skin.
  • LHA tends to exfoliate corneocytes individually, producing a smoother, more uniform surface renewal.
  • It is commonly formulated for acne, uneven texture, and signs of photoaging.

Frequently asked

How does LHA differ from regular salicylic acid?

LHA is a larger, more oil-soluble derivative of salicylic acid that penetrates more slowly and exfoliates cell by cell, which many find gentler. Both are beta-hydroxy-type ingredients suited to oily and congestion-prone skin.

Is LHA good for acne-prone skin?

Its ability to penetrate sebum and exfoliate within pores makes it a popular choice for blemish-prone and oily skin. Results vary by individual and formulation, and persistent acne should be discussed with a dermatologist.

Related topics

This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.

Encyclopedia

Further reading

This entry was written and checked against the sources below. They are published by clinical and scientific bodies, they are listed most readable first, and each one opens in a new tab. They are background for the whole entry rather than footnotes to individual sentences.

  1. Applications of hydroxy acids: classification, mechanisms, and photoactivity PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  2. The Use of Lipohydroxy Acid in Skin Care and Acne Treatment PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov
  3. Mechanism of action of a lipophilic salicylic acid derivative on normal skin PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov
  4. Randomized trial comparing a chemical peel containing a lipophilic hydroxy acid derivative of salicylic acid with a salicylic acid peel in subjects with… PubMed Peer-reviewed (abstract) pubmed.ncbi.nlm.nih.gov
  5. Cosmeceuticals StatPearls (NCBI Bookshelf) Reference text ncbi.nlm.nih.gov
  6. Cosmeceuticals in photoaging: A review PubMed Central Peer-reviewed, open access pmc.ncbi.nlm.nih.gov

SYNC does not publish medical advice. Nothing here replaces a consultation with a doctor or a pharmacist about your own skin.