Percutaneous Absorption

Percutaneous Absorption — the process by which a substance applied to the skin passes through its layers and, in some cases, into the bloodstream. It typically involves an ingredient dissolving into the outer barrier, diffusing through the stratum corneum, and moving into deeper, living tissue. The rate and extent depend on the ingredient's properties, the formula, and the skin's condition and location.

Key points

• Percutaneous absorption is the movement of a topically applied substance through the skin's layers.
• The main route is through the stratum corneum, with smaller contributions from hair follicles and sweat glands.
• Factors such as molecular size, solubility, concentration, skin hydration, and body site all affect absorption.
• Damaged or compromised skin generally absorbs substances more readily than intact, healthy skin.

Frequently asked

Is percutaneous absorption the same as penetration?

They are related, but penetration usually refers to entering the skin's layers, while percutaneous absorption often implies passage all the way through, potentially reaching the bloodstream.

Does skin condition affect percutaneous absorption?

Yes, factors like hydration, barrier damage, and the area of the body can significantly change how much of a substance is absorbed.

Related topics

• What Is a Humectant?
• What Is the Skin Barrier?

This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.