AGEs (Advanced Glycation End Products)
AGEs (Advanced Glycation End Products) — the stable compounds that form at the final stage of glycation, when sugars permanently cross-link with proteins or lipids. In skin they are associated with stiffened collagen, dullness, and diminished elasticity, and once formed they are difficult for the body to break down.
Key points
- They represent the end stage of the glycation process and accumulate gradually with age.
- In skin they cross-link collagen and elastin, making these fibers rigid and less resilient.
- They can form within the body and also be consumed in foods cooked at high, dry heat.
- UV exposure is thought to accelerate their formation and their damaging effects on skin.
Frequently asked
What is the difference between glycation and AGEs?
Glycation is the ongoing reaction between sugars and proteins, while AGEs are the stable end products that result once that reaction is complete.
Can you prevent AGEs from building up in skin?
You cannot fully prevent them, but limiting excess sugar, protecting skin from UV, and using antioxidants may help slow their accumulation.
Related topics
This is a foundational entry in the SYNC Skin Encyclopedia and is expanded over time. Educational information only — not medical advice.
